Gene variants associated with a rare autoimmune disorder called Addison's disease have been pinpointed, according to researchers.
"By studying the single largest collection of samples from patients with Addison's disease, we've been able to carry out the first genetic study of the disease that spans the entire human genome," said study co-leader Daniel Eriksson, a researcher in the experi...
Stem cell transplants may have long-lasting benefits for some people with aggressive cases of multiple sclerosis, a new study suggests.
Italian researchers found that among 210 multiple sclerosis (MS) patients who received a stem cell transplant -- with cells from their own blood -- two-thirds saw no worsening in their disability 10 years out.
Just over 200,000 Americans have the autoimmune disorder lupus, and minority women are at highest risk, according to a new study.
It's the first estimate of how widespread the disease is in the United States. The number comes close to reclassifying lupus as a rare disease, defined as an illness affecting 200,000 Americans or fewer, the researchers said.
Blood vessel damage and inflammation in the brains of deceased COVID-19 patients suggest the damage is not caused by the virus, but the body's immune response to it.
Researchers from the U.S. National Institutes of Health (NIH) consistently found signs of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after getting COVID-19.
Rheumatoid arthritis patients who are in remission have significantly higher body temperatures than people without the joint disease, new research shows.
The study included 32 rheumatoid arthritis patients who were in remission and a healthy "control" group of 51 people without rheumatoid arthritis, who all had thermal scans of different areas of their feet.
When the new coronavirus pandemic first began, respiratory distress immediately became the hallmark of severe COVID-19 illness. News reports focused on the inability to breathe, low oxygen saturation levels and the alarming need for ventilators.
But six months later, experts are becoming increasingly concerned about a very different COVID-19 phenomenon, one that spares the lungs only ...
Scientists knew that dangerous T-cells lived in the pancreases of people with type 1 diabetes, but a new study shows they also take up residence in the pancreases of healthy individuals.
Researchers from the La Jolla Institute for Immunology in California used a new staining technique to show where these cells had gathered in human tissue samples. They were surprised that even tissue ...
A recently approved rheumatoid arthritis medication appears to be an effective second-line therapy when biologic treatments start to fail, a new clinical trial reports.
Arthritis sufferers treated with upadacitinib had a significantly greater reduction in their symptoms and disease activity than people treated with a standard disease-modifying antirheumatic drug (DMARD), said co-resea...
Adding a newer drug to standard therapy might help control kidney complications caused by the autoimmune disease lupus, a new clinical trial suggests.
The researchers found that adding the drug, called belimumab, improved patients' likelihood of responding to treatment. That meant a reduction in protein in the urine -- a tell-tale sign of kidney inflammation -- and no significant loss...
When actress Alyssa Milano was first struck by the new coronavirus back in March, her symptoms mirrored the classic signs of COVID-19: fever, headache, loss of smell, chest heaviness, extreme breathing difficulties and a bad stomach.
"It felt like I was dying," Milano, 47, posted on Twitter.
Those symptoms have persisted, and even expanded to include vertigo, heart palpitati...
An infusion of cells that dampen the body's immune response might help people with severe cases of the new coronavirus recover more quickly, a new report suggests.
Two patients so sick with COVID-19 that they'd been put on a ventilator improved quickly when given an infusion of regulatory T-cells, which are cells that check the immune system and prevent it from overreacting to an infe...
A blood test may predict which COVID-19 patients are likely to need a ventilator.
This finding could lead to a scoring system that would flag at-risk patients for closer monitoring and to personalized treatments. It may also help explain how diabetes makes outcomes worse, according to researchers from the University of Virginia School of Medicine.
There's new evidence that a 2,000-year-old medicine might offer hope against a modern scourge: COVID-19.
The medication, called colchicine, is an anti-inflammatory taken as a pill. It's long been prescribed for gout, a form of arthritis, and its history goes back centuries. The drug was first sourced from the autumn crocus flower.
HIV may not be the death sentence it was 20 or 30 years ago, but people who are HIV-positive still face much shorter lives than other adults -- even if they're treated with medications that make the virus undetectable.
A new study reports that people who were HIV-positive at age 21 had an average life expectancy of 56 years -- nine years fewer than their virus-free peers.
Air pollution might increase the risk for multiple sclerosis (MS), Italian researchers report.
They found that in places with low levels of tiny particles of air pollution called particulate matter, the risk for MS was lower than in areas where those levels were high. In urban areas, the risk was 29% higher than in rural areas.
The severity of COVID-19 illness may be influenced by what researchers call "cytokine storms."
In a new study, investigators assessed 522 COVID-19 patients, aged 5 days to 97 years, who were admitted to two hospitals in Wuhan, China, in December and January. The study also included a "control group" of 40 healthy people.
Compared to the control group, 76% of COVID-19 pat...
Hydroxychloroquine is a key therapy for the autoimmune disease lupus, but interest in it as a potential COVID-19 treatment could make it hard for lupus patients to obtain, experts warn.
Hydroxychloroquine is the only medication known to increase survival in patients with systemic lupus. That's the most common form of lupus, a disease in which the immune system attacks different parts ...
As researchers hunt for ways to treat severe COVID-19 infections, a new trial will ask whether an old arthritis drug can prevent serious complications in the first place.
The medication, called colchicine, is an oral anti-inflammatory that has long been prescribed for gout, a form of arthritis. Its history goes back thousands of years, and the drug was first sourced from the autumn cr...
One of the few bright spots in the COVID-19 pandemic has been the perception that children are mostly spared from its worst effects. But what about kids already at risk of contracting serious infections due to a compromised immune system? Do they have the same protection?
"One group we always worry about when it comes to viral illnesses is immunocompromised children," said Dr. Reggie...
People with asthma and other lung diseases are at increased risk for serious complications from COVID-19, caution experts from the American Lung Association.
"Everyone's health is at risk from COVID-19, and those living with a lung disease or who are immunocompromised may be more vulnerable to the impacts of the virus," said Dr. Albert Rizzo, the association's chief medical officer.
New research suggests that having an underlying health condition might be one of the most significant risk factors for developing a severe case of COVID-19.
Scientists at the U.S. Centers for Disease Control and Prevention took a look at a group of U.S. adult COVID-19 patients and found roughly three-quarters of those who wound up in the hospital had at least one underlying health iss...
Smokers and vapers who get COVID-19 can probably expect a more severe infection, health experts warn.
Many advisories have focused on the risk facing older people, those with chronic conditions such as diabetes, and people with compromised immune systems, such as cancer patients. But doctors also caution that users of electronic cigarettes and tobacco are more in danger from the new ...
As the coronavirus pandemic continues its relentless spread around the world, the greatest worry has been for older people. But experts stress that age is not the sole determinant of risk for severe illness or death.
"The elderly and people with chronic diseases have the highest risk. If you're not sure if you're at a higher risk, talk to your doctor," said Dr. Susan Bleasdale, a spo...
A variant of a common herpes virus may play a role in the development of multiple sclerosis (MS), Swedish researchers say.
They analyzed the blood of about 8,700 MS patients and a control group of more than 7,200 people without MS. They were looking for antibodies against proteins of two variants (A and B) of human herpesvirus 6 (HHV-6), which has been linked with MS.
The latest version of the so-called artificial pancreas system helped people with type 1 diabetes gain even better control of their blood sugar levels than current technology does, a new study reports.
The device combines an insulin pump, a continuous glucose monitor and a computer algorithm. The system measures blood sugar levels and delivers insulin automatically when levels rise. ...